On April 15, 2021, Deadline announced that Mikkelsen had joined the production of the fifth theatrical Indiana Jones film. He had previously worked with Lucasfilm Ltd. in 2016's Rogue One: A Star Wars Story, the first installment of the Star Wars Anthology series, where he played Galen Walton Erso.
Mikkelsen is perhaps best known for his roles in movies like the Pusher trilogy, Coco Chanel & Igor Stravinsky, A Royal Affair, King Arthur, The Hunt, Doctor Strange, and the Oscar-winning Another Round (Best International Feature Film). He rose to worldwide fame for his portrayal of Le Chiffre in the James Bond film Casino Royale (starring Daniel Craig) and has also played the iconic role of Dr. Hannibal Lecter in the short-lived Hannibal television series. Recent movies include Chaos Walking and Riders of Justice. He has also been cast in the role of Gellert Grindelwald in the Fantastic Beasts film series, beginning with its upcoming third installment.