In 1957, Indiana Jones traveled there with Mutt Williams searching for Harold Oxley. Arriving by plane, they unloaded Williams' motorcycle from the airport, and drove into town. In a marketplace, Jones spoke Quechua to the locals, and learned that a man fitting Oxley's description has been committed to the local sanatorium several months prior. At the sanatorium dedicated to Anthony de Padua, the two learned from a nun that Oxley had been liberated by some unknown men. Examining his room in the asylum, they found carvings on the wall of a skull, and the word "Return" in several languages. With the help of a broom, Jones and Williams found a map on the floor, showing the location of Orellana's Tomb, and set off for the Chauchilla Cemetery. Unfortunately, they were unaware that they had been followed in town by Jones' friend-turned-traitor, George McHale.
Behind the scenes
In Indiana Jones and the Kingdom of the Crystal Skull, Indiana Jones and Mutt Williams's flight path seemingly ends at Cusco before the scene changes to their having arrived at the Aeropuerto de Nazca. Nazca is actually located to the southwest of Cusco and would require an additional, unseen flight to reach there.