Santiago (or Santiago de Cuba) is second major city of Cuba, after Havana, and is located on the southeastern coast of the island.

In the summer of 1943, Indiana Jones and George McHale used Santiago as their starting point for a series of flights to get them to Haiti. McHale had found Raul, the pilot of Rosita, and the three had flown from the city to Guantanamo, then Baraco and across the Windward Passage before the plane engine died and the plane crashed.

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