On June 11, 2021, photos were leaked from the filming of the fifth theatrical Indiana Jones film in Scotland, showing Jones on location with Harrison Ford. He was then subsequently confirmed to be a part of the cast by the Daily Mail later that day. He previously worked with producer Steven Spielberg in The Adventures of Tintin (with Daniel Craig).
Jones is perhaps best known for his breakthrough role as Truman Capote in the biopic Infamous (also with Daniel Craig), after previously appearing in numerous cinematic supporting roles. Other prominent film roles played by Jones include Dobby the House Elf in the second and seventh films of the Harry Potter film series (appearing with Julian Glover in the former and Michael Byrne, John Hurt and Timothy Spall in the latter); Arnim Zola in the Marvel Cinematic Universe, beginning with the films Captain America: The First Avenger (directed by Joe Johnston) and Captain America: The Winter Soldier (with Thomas Kretschmann); and Claudius Templesmith in The Hunger Games and The Hunger Games: Catching Fire (with Jeffrey Wright).
Additional feature film acting credits for Jones include Orlando, the 1998 film adaptation of Les Misérables (directed by Bille August), Ever After (with Jeroen Krabbe), Hotel Splendide (again with Daniel Craig), Ladies in Lavender (with his father, Freddie Jones), The Mist (adapted and directed by Frank Darabont), W. (also with Jeffrey Wright), Sex & Drugs & Rock & Roll (with Ray Winstone), the 2011 film adaptation of Tinker Tailor Soldier Spy (also with John Hurt), My Week with Marilyn (with Pip Torrens), Snow White and the Huntsman (also with Ray Winstone), the 2016 film adaptation of Dad's Army (with Catherine Zeta Jones), Atomic Blonde, Jurassic World: Fallen Kingdom, Christopher Robin (with Oliver Ford Davies) and A Boy Called Christmas (with Jim Broadbent).
Some of the extensive television credits by Jones include guest roles on Doctor Who (as the Dream Lord, a psychic manifestation of The Doctor), Agatha Christie's Poirot (in its adaptation of Murder on the Orient Express) and Sherlock; recurring roles on Midsomer Murders and The Dark Crystal: Age of Resistance; and regular roles on Detectorists, Wayward Pines and Don't Forget the Driver (which he also co-created) as well as appearances in the miniseries Aristocrats (with Julian Fellowes), The Way We Live Now (also with Oliver Ford Davies), Elizabeth I (with Ian McDiarmid) and Titanic (written by Julian Fellowes) and the TV movies The Old Curiosity Shop, Mo, The Girl (as Alfred Hitchcock), Marvellous and the MCU shows Agent Carter and What If...? (with Clark Gregg).